Manoj Raghavan is a consultant haematologist based at the Centre for Clinical Haematology. Manoj works closely with Professor Charlie Craddock, and has a strong interest in myeloid malignancies.
Clinical Senior Lecturer, School of Cancer Sciences, University of Birmingham Consultant Haematologist, University Hospitals Birmingham
Background and Research focus
Following an undergraduate medical degree at the University of Cambridge, Manoj graduated in Medicine from St George’s Hospital Medical School in 1994, and went on to train in haematology at University College Hospital, London. He then carried out a PhD at Barts and the London School of Medicine and Dentistry, completing his studies in 2008. He was recruited to Birmingham in late 2010, taking up the post of Clinical Senior Lecturer at University of Birmingham, and Consultant Haematologist at University Hospitals Birmingham.
Manoj has a major interest in the molecular and genetic basis of dysregulated haematopoiesis that characterizes myeloid malignancies. Increased understanding in this area has allowed development of new therapeutic strategies targeting underlying abnormalities within leukaemic cells. Manoj, together with Professor Craddock, is leading development of epigenetic therapies in patients with high risk myeloid malignancies. These studies, which involved close collaboration with Dr Sylvie Freeman, incorporate quantitation of leukaemic stem/progenitor populations with the aim of developing a novel biomarker of disease response.
Haematological malignancies; myelodysplasia; acute myeloid leukaemia; acute lymphoblastic leukaemia; genome wide association studies; haematopoiesis; leukaemic stem cells; chromosomal amplifications; epigenetic modification; leukemogenesis; DNA methylation.
In addition to leading his own research group, Manoj is a member of the Myelodysplasia subgroup of the NCRI Haematology Oncology Clinical Studies Group.
Oliver C Goodyear, Mike Dennis, Nadira Y Jilani, Justin Loke, Shamyla Siddique, Gordon Ryan, Jane Nunnick, Rahela Khanum, Manoj Raghavan, Mark Cook, John a Snowden, Mike Griffiths, Nigel Russell, John Yin, Charles Crawley, Gordon Cook, Paresh Vyas, Paul Moss, Ram Malladi, Charles F Craddock (2012) Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)., 3361-9. In Blood 119 (14).
C Craddock, L Quek, N Goardon, S Freeman, S Siddique, M Raghavan, a Aztberger, a Schuh, D Grimwade, a Ivey, P Virgo, R Hills, T McSkeane, J Arrazi, S Knapper, C Brookes, B Davies, a Price, K Wall, M Griffiths, J Cavenagh, R Majeti, I Weissman, a Burnett, P Vyas (2012) Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia., 1-29. In Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K.
Marwa H Saied, Jacek Marzec, Sabah Khalid, Paul Smith, Thomas a Down, Vardhman K Rakyan, Gael Molloy, Manoj Raghavan, Silvana Debernardi, Bryan D Young (2012) Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats., e33213. In PloS one 7 (3).
Manoj Raghavan, Manu Gupta, Gael Molloy, Tracy Chaplin, Bryan D Young (2010) Mitotic recombination in haematological malignancy., 96-103. In Advances in enzyme regulation 50 (1).
Manoj Raghavan, Manu Gupta, Tracy Chaplin, Sabah Khalid, T. Andrew Lister, Bryan D. Young (2009) Genome-Wide Micro-Deletions and Amplifications Acquired at Relapse in Acute Myeloid Leukemia, 1. In ASH Annual Meeting Abstracts 114 (9).
Manu Gupta, Manoj Raghavan, Rosemary E Gale, Claude Chelala, Christopher Allen, Gael Molloy, Tracy Chaplin, David C Linch, Jean-Baptiste Cazier, Bryan D Young (2008) Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia., 729-39. In Genes, chromosomes & cancer 47 (9).
Manoj Raghavan, Lan-Lan Smith, Debra M Lillington, Tracy Chaplin, Ioannis Kakkas, Gael Molloy, Claude Chelala, Jean-Baptiste Cazier, James D Cavenagh, Jude Fitzgibbon, T Andrew Lister, Bryan D Young (2008) Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia., 814-21. In Blood 112 (3).
Bryan D Young, Silvana Debernardi, Debra M Lillington, Spyros Skoulakis, Tracy Chaplin, Nicola J Foot, Manoj Raghavan (2006) A role for mitotic recombination in leukemogenesis., 90-7. In Advances in enzyme regulation.
Jon C Strefford, Frederik W van Delft, Hazel M Robinson, Helen Worley, Olga Yiannikouris, Rebecca Selzer, Todd Richmond, Ian Hann, Tony Bellotti, Manoj Raghavan, Bryan D Young, Vaskar Saha, Christine J Harrison (2006) Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21., 8167-72. In Proceedings of the National Academy of Sciences of the United States of America 103 (21).
Manoj Raghavan, Debra M Lillington, Spyros Skoulakis, Silvana Debernardi, Tracy Chaplin, Nicola J Foot, T Andrew Lister, Bryan D Young (2005) Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias., 375-8. In Cancer research 65 (2).