Professor David Adams

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Professor David Adams is examining the role of chronic inflammation in promoting liver cancer, and exploring dendritic cell vaccination approaches to target hepatocellular carcinoma.
Position:

Professor of Hepatology, Dean of Medicine, College of Medical and Dental Sciences, Medical School Building, University of Birmingham. 

Email: d.h.adams@bham.ac.uk

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Background and Research focus

Professor Adams and his group are focussed on understanding how leukocyte-endothelial interactions regulate the recruitment of effector cells in chronic liver disease and defining the molecular mechanisms used by hepatic endothelium to modulate leukocyte entry from the blood. More recently, they have exploited this information to develop cell therapy for liver disease within the National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU) Centre. This includes not only blocking pathways implicated in the recruitment of damaging effector cells but also promoting the recruitment of therapeutic cells including dendritic cells, stem cells and regulatory T cells that could potentially be used to manipulate immune responses in patients in vivo.

Expertise

Liver transplantation; liver disease; alcoholic liver disease; autoimmune liver disease and immune regulation; cancer immunotherapy.

Other activities

In addition to leading his own research group, Ben is director of the University’s Cancer David Adams is the director of the Centre for Liver Research and the NIHR Birmingham Liver BRU and lead for translational research in the MRC Centre for Immune Regulation. In addition to this, David serves as a Consultant Physician within the Liver Unit of the Queen Elizabeth Hospital. He has supervised >25 PhD and MD students in various fields of immunology including inflammatory liver disease, leucocyte trafficking and immune regulation. David is a leading expert in the field of liver disease having published over 200 scientific articles in peer review journals. He also sits on the editorial board of Liver Transplantation, Journal of Physiology and Journal of Hepatology.  David is a regular speaker at International and Regional meetings on liver disease.

Publications

Fletcher NF, Sutaria R, Jo J, Barnes A, Blahova M, Meredith LW, Cosset FL,Curbishley SM, Adams DH, Bertoletti A, McKeating JA. Activated macrophagespromote hepatitis C virus entry in a tumor necrosis factor-dependent manner. Hepatology. 2013 Oct 29.

Li KK, Adams DH. Antitumor CD8(+) T cells in hepatocellular carcinoma: Present but exhausted. Hepatology. 2013 Oct 9.

Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology. 2013 Jan;57(1):385-98.

Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology. 2013 Jan;57(1):385-98.

Ward ST, Weston CJ, Hepburn E, Damery S, Hejmadi RK, Morton DG, Middleton G, Ismail T, Adams DH. Evaluation of serum lysyl oxidase as a blood test for colorectal cancer. Eur J Surg Oncol. 2013 Nov 6. pii: S0748-7983(13)00871-8.

Bhogal RH, Weston CJ, Curbishley SM, Adams DH, Afford SC. Autophagy: a cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress. Autophagy. 2012 Apr;8(4):545-58.

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klenerman P, Eksteen B, Adams DH.
J Hepatol. 2012 Nov;57(5):1044-51.

Shetty S, Bruns T, Weston CJ, Stamataki Z, Oo YH, Long HM, Reynolds GM, Pratt G, Moss P, Jalkanen S, Hubscher SG, Lalor PF, Adams DH. Recruitment mechanisms of primary and malignant B cells to the human liver. Hepatology. 2012 Oct;56(4):1521-31.

Liaskou, E. Karikoski, M Reynolds GM, Lalor PF, Weston CJ, Pullen N, Salmi M, Jalkanen S & DH Adams. Regulation of MAdCAM-1 expression In humans & mice by amine oxidase activity. Hepatology 2011; 53: 661-72.

Shetty S, Weston CJ, Oo YH, Westerlund N, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen SJ, Lalor PF & DH Adams. CLEVER-1 mediates Treg transmigration across liver endothelium. Journal of Immunology 2011; 186: 4147-55.