Professor David Briggs

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David Briggs is head of Histocompatibility and Immunogenetics  at NHS Blood and Transplant, Birmingham. He has a long-standing research interest in the immunogenetics of transplantation, in particular stem cell transplantation.
Position:

Professor of Immunogenetics

Consultant Clinical Scientist

Head of the Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Vincent Drive, Birmingham

Email: David.Briggs@nhsbt.nhs.uk

Research focus

David leads the Department of Histocompatibility and Immunogenetics at NHSBT, Birmingham, which provides a central H&I service to both solid organ and stem cell transplant units in the West Midlands, for example in HLA typing of patients and potential donors, prior to transplantation.

The laboratory focusses  mainly on tissue matching, transplantation immunology and genetic analyses, and is at the forefront of scientific research and development in H&I,  with a progressive approach and close clinical and academic links with all university hospital transplant units in the W Midlands. As Professor of Immunogenetics, David leads his own laboratory-based research programme aimed at developing novel approaches to typing donor tissue, and at identifying genetic polymorphisms in both patients and donors that influence the outcome of transplants. A major focus is stem cell transplantation (SCT), an area in which he has a long standing collaboration with Professor Moss. A particular subject David has studied in detail is polymorphisms in Natural Killer Cell receptors and their ligands in relation to SCT outcome.

Expertise

transplantation genetics; stem cell transplantation; immunogenetics; HLA typing; Killer Immunoglobulin-like Receptors (KIRs); HLA-C; Natural Killer cells;  NKG2D; ULBP; MICA; polymerase chain reaction; diagnostic assay;  antibody;

Other activities

David is a  member of the Cancer Immunology and Immunotherapy Centre Advisory Board.

Publications

Antoun A, Vekaria D, Salama RA, Pratt G, Jobson S, Cook M, Briggs D, Moss P. The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly influences the clinical outcome of allogeneic stem cell transplantation. Br J Haematol. 2012 Dec;159(5):589-98.

Antoun A, Jobson S, Cook M, O’Callaghan CA, Moss P, Briggs DC. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. Hum Immunol. 2010 Jun;71(6):610-20.

Smith HJ, Hanvesakul R, Morgan MD, Bentall A, Briggs D, Clark F, Pratt G, Moss P, Larch M, Ball S. Chronic graft versus host disease is associated with an immune response to autologous human leukocyte antigen-derived peptides. Transplantation. 2010 Sep 15;90(5):555-63.

Antoun A, Jobson S, Cook M, Moss P, Briggs D. Ethnic variability in human leukocyte antigen-E haplotypes. Tissue Antigens. 2009 Jan;73(1):39-45.

Cook M, Briggs D, Craddock C, Mahendra P, Milligan D, Fegan C, Darbyshire P,  Lawson S, Boxall E, Moss P. Donor KIR genotype has a major influence on the rate  of cytomegalovirus reactivation following T-cell replete stem cell transplantation. Blood. 2006 Feb 1;107(3):1230-2. Epub 2005 Oct 20. PubMed PMID:  16239436.

Cook MA, Milligan DW, Fegan CD, Darbyshire PJ, Mahendra P, Craddock CF, Moss PA, Briggs DC. The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia. Blood. 2004 Feb 15;103(4):1521-6. Epub 2003 Sep 22. PubMed PMID: 14504099.

Cook MA, Moss PA, Briggs DC. The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups. Eur J Immunogenet. 2003 Jun;30(3):213-21. PubMed PMID: 12787000.