Dr Ye Htun Oo is a Medical Research Council Clinician Scientist and Honorary Consultant Hepatologist at the UHB NHS Foundation Trust, with a clinical focus on liver transplantation and viral and autoimmune hepatitis.
Medical Research Council Clinician Scientist, School of Immunity and Infection, College of
Medical and Dental Sciences, University of Birmingham
Background and Research focus
Ye is a MRC Clinician Scientist (awarded 2012) with a long standing research interest in liver transplantation, viral and autoimmune hepatitis. His team is focused on several basic research programmes that involve studying pathogenesis of liver inflammation and repair in autoimmune liver diseases (tolerance breakdown), fibrosis in viral infection, gut & liver link mucosal immunology and operational tolerance. Collectively, these studies will inform future efforts to develop cell and cytokine therapeutic approaches for patients with autoimmune, viral related liver diseases and in liver transplantation. His team are interested in gaining a comprehensive understanding of basic research and to translate these findings for patient care. One of his long term objectives is to restore immune homeostasis in autoimmune liver diseases with GMP grade autologous regulatory T cells therapy.
Liver transplantation; autoimmune liver diseases; viral immunology; regulatory T cells; Mucosa immunology; liver inflammation and fibrosis.
Ye leads a small team consisting of post-doc fellows, one PhD student and one clinical fellow. He also supervises interacted medical students. Ye has received funding from the MRC, NIHR and the University of Birmingham Charity grant. He is national lead for UK-AIH immunophenotyping in Type 1 AIH patients. In addition to his research commitments, Ye is an Honorary Consultant Hepatologist in Liver Transplant and Hepato-biliary Department at University Hospital Birmingham NHS Foundation Trust. Here he conducts dedicated viral and autoimmune hepatitis clinics, involved in direct activating antiviral (DAA) clinical trials. In addition, Ye serves as a MRCP Practical Assessment of Clinical Examination Skills (PACES) examiner which involves assessing core clinical skills of doctors. He also makes substantial contributions to teaching liver transplantation and immunology by regularly delivering lectures on the BMedSc (Medical Science) and MSc (in Immunology) courses at the University of Birmingham. Finally, Ye is an active member of the British, European and American Associations for study of liver diseases, British Viral Hepatitis Group and UK-AIH.
Afford SC, Humphreys EH, Reid DT, Russell CL, Banz VM, Oo Y, Vo T, Jenne C, Adams DH, Eksteen B. Vascular cell adhesion molecule 1 expression by biliary epithelium promotes persistence of inflammation by inhibiting effector T-cell apoptosis. Hepatology. 2014 May;59(5):1932-43.
Oo YH, Sakaguchi S. Regulatory T-cell directed therapies in liver diseases. J Hepatol. 2013Nov;59(5):1127-34.
Tuncer C, Oo YH, Murphy N, Adams DH, Lalor PF. The regulation of T-cell recruitment to the human liver during acute liver failure. Liver Int. 2013 Jul;33(6):852-63.
Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klenerman P, Eksteen B, Adams DH. CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J Hepatol. 2012 Nov;57(5):1044-51.
Oo YH, Adams DH. Regulatory T cells and autoimmune hepatitis: defective cells or a hostile environment?. J Hepatol. 2012 Jul;57(1):6-8.
Barnes E, Folgori A, Capone S, Swadling L, Aston S, Kurioka A, Meyer J, Huddart R, Smith K, Townsend R, Brown A, Antrobus R, Ammendola V, Naddeo M, O’Hara G, Willberg C, Harrison A, Grazioli F, Esposito ML, Siani L, Traboni C, Oo Y, Adams D, Hill A,Colloca S, Nicosia A, Cortese R, Klenerman P. Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. Sci Transl Med. 2012 Jan 4;4(115):115ra1.
Zoutendijk R, Reijnders JG, Brown A, Zoulim F, Mutimer D, Deterding K, Petersen J, Hofmann WP, Buti M, Santantonio T, van Bömmel F, Pradat P, Oo Y, Luetgehetmann M, Berg T, Hansen BE, Wedemeyer H, Janssen HL. Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response.; VIRGIL Surveillance Study Group. Hepatology. 2011 Aug;54(2):443-51.
YH Oo, C Weston, P F Lalor, S Curbishley, DR Withers, GM Reynolds, S Shetty, J Harki, JC Shaw, B Eksteen, SG Hubscher, LS Walker, DH Adams. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. Journal of Immunology 2010 Mar 15;184(6):2886-98.
Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, YH Oo, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R, Klenerman P. Analysis of CD161 expression on human CD8+ T cells defines a functional subset with tissue-homing properties. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11).
Tacrolimus and Cyclosporin doses and blood levels in Hepatitis C and Alcoholic liver disease patients after liver transplantation. YH Oo, T Dudley, P Nightingale, G Haydon, D Mutimer. Liver Transplantation 2008, Jan 14(1) 81-87.